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Acknowledgements We would like to thank the medical practitioners from the Doctor Association Devoted to New Health and healthcare practitioners in Songjiang district and Fengxian district for field work assistance, and Professor Michael Engelau (Center for Diseases Control and Prevention, US) for giving suggestions and comments on this manuscript

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Brooke Shields is well known for a number of high-profile touchstones, including but not limited to playing a child prostitute in 1978s Pretty Baby